A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) A61K 35/76 (2006.01) C12N 7/04 (2006.01)
Patent
CA 2352043
The invention described herein relates to the discovery of methods and compositions for the inhibition of growth and/or migration of cells that have the P antigen, including but not limited to, cells of hematopoietic origin and endothelial cells. More specifically, parvovirus capsid particles or fragments of parvovirus capsid proteins are used to manufacture medicaments that can be administered to a subject to inhibit hematopoietic progenitor cell growth (e.g., prior to stem cell transplantation), endothelial cell growth, (e.g., as an anti-tumorigenesis treatment or to prevent restenosis or fibrotic build up following prosthetic implantation), or to prevent disorders that involve the abnormal proliferation of cells that have the P antigen (e.g., polycytemia vera).
L'invention concerne la découverte de méthodes et de compositions permettant d'inhiber la croissance et/ou la migration de cellules porteuses de l'antigène P, notamment, entre autres, les cellules d'origine hématopoïétique et des cellules endothéliales. L'invention concerne, en particulier, l'utilisation de particules de capsides de parvovirus ou de fragments de protéines de capsides de parvovirus dans la fabrication de médicaments susceptibles d'être administrés à un patient dans le but d'inhiber la croissance des progéniteurs hématopoïétiques (par exemple, avant transplantation de cellules souches), la croissance des cellules endothéliales (par exemple, en tant que traitement anti-tumorigenèse ou pour empêcher la resténose ou l'accumulation de fibres après implantation d'une prothèse) ou pour empêcher les troubles impliquant la prolifération anormale de cellules porteuses de l'antigène P (par exemple, la polyglobuline essentielle).
Broliden Kristina
Westgren Magnus
Sim & Mcburney
Tripep Ab
LandOfFree
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