C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 62/34 (2006.01) A61K 31/192 (2006.01) A61K 31/337 (2006.01) A61K 31/437 (2006.01) A61P 3/10 (2006.01) C07D 305/06 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2703217
Tricyclic compounds containing a cyclopropanecarboxylic acid fused to a bicyclic ring, including pharmaceutically acceptable salts, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
L'invention concerne des composés tricycliques contenant un acide cyclopropanecarboxylique fusionné à un noyau bicyclique, y compris les sels acceptables du point de vue pharmaceutique de ceux-ci. Ces composés sont des agonistes du récepteur couplé aux protéines G 40 (GPR40) et s'utilisent en tant que composés thérapeutiques en particulier dans le traitement du diabète de type 2, et dans le traitement d'états qui sont souvent associés à cette maladie, y compris l'obésité et les troubles lipidiques, tels que la dislipidémie, l'hyperlipidémie, l'hypercholestérolémie et l'hypertriglycéridémie mixtes ou diabétiques.
Finke Paul E.
Kim Dooseop
Liang Gui-Bai
Liao Xibin
Lin Songnian
Gowling Lafleur Henderson Llp
Merck Sharp & Dohme Corp.
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