Injectable implants for tissue augmentation and restoration

Details Injectable implants for tissue augmentation and restoration Injectable implants for tissue augmentation and restoration

A - Human Necessities

61

L

A61L 27/00 (2006.01) A61F 2/02 (2006.01) A61F 2/56 (2006.01) A61K 9/14 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) A61K 38/04 (2006.01) A61K 38/16 (2006.01) A61L 27/22 (2006.01) C08F 38/00 (2006.01) C08F 283/00 (2006.01) C08F 293/00 (2006.01) D02G 3/00 (2006.01) A61B 17/88 (2006.01) A61F 2/28 (2006.01) A61F 2/30 (2006.01) A61F 2/44 (2006.01) A61F 2/46 (2006.01)

Patent

CA 2319558

A method for tissue augmentation in a mammal is provided comprising injecting a polymer at a tissue site in need of augmentation and having a tissue temperature, the polymer comprising repeating peptide monomeric units selected from the group consisting of nonapeptide, pentapeptide and tetrapeptide monomeric units, wherein the monomeric units form a series of .beta.-turns separated by dynamic bridging segments suspended between the .beta.-turns, wherein the polymer has an inverse temperature transition Tt less than the tissue temperature, and wherein the polymer is injected as a water solution at coacervate concentration in the substantial absence of additional water. A kit containing the injectable bioelastic polymer and a syringe is also provided.

L'invention concerne un procédé d'accroissement de tissu chez un mammifère, qui consiste à injecter un polymère dans un site à l'intérieur du tissu qui a besoin d'accroissement et qui possède une certaine température, le polymère comprenant des unités monomères de peptides à répétition, sélectionnées dans le groupe comprenant des unités monomères de nonapeptide, de pentapeptide et de tetrapeptide, les unités monomères formant une série de coudes bêta séparés par des segments dynamiques de pontage, suspendus entre les coudes bêta, le polymère possédant une température de transition inverse T¿t? qui est inférieure à la température du tissu. Le polymère est injecté sous la forme d'une solution aqueuse à une concentration de coacervation et sensiblement en absence de toute eau supplémentaire. L'invention concerne aussi un kit comprenant le polymère bioélastique injectable et une seringue.

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