Inhibitors of cyclophilin rotamase activity

Details Inhibitors of cyclophilin rotamase activity Inhibitors of cyclophilin rotamase activity

A - Human Necessities

61

K

A61K 38/13 (2006.01) A61P 25/00 (2006.01) C12N 9/90 (2006.01)

Patent

CA 2238050

This invention relates to the method of using neurotrophic cyclophilin inhibitor compounds having an affinity for cyclophilin-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.

Dans la présente invention, on divulgue une méthode d'utilisation de composés neurotrophiques inhibiteurs des cyclophilines qui possèdent une affinité pour les immunophilines de type cyclophiline en tant qu'inhibiteurs de l'activité enzymatique associée à des protéines d'immunophiline. La présente invention concerne plus particulièrement des inhibiteurs de l'activité enzymatique de la rotamase ou de la peptidyl-propyle-isomérase.

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