Method for detecting transient protein interactions and drug...

Details Method for detecting transient protein interactions and drug... Method for detecting transient protein interactions and drug...

C - Chemistry, Metallurgy

07

K

C07K 1/22 (2006.01) C07K 1/14 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2535860

The invention relates to methods and kits for separating, and optionally analyzing, substoichiometrically interacting ligands from a high abundance ligand of interest in an affinity matrix system. The methods comprising immobilizing a complex of a first and second ligand to an affinity matrix, wherein the second ligand is bound to the matrix, and subsequently eluting the first ligand from the matrix. In addition, the methods and kits can be used for drug discovery.

Cette invention porte sur des procédés et des trousses permettant de séparer, et éventuellement d'analyser, des ligands à interaction sous-stoechiométrique d'un ligand d'intérêt très abondant dans un système à matrice d'affinité. Ces procédés consistent à immobiliser un complexe composé d'un premier et d'un second ligand sur une matrice d'affinité, lequel second ligand est lié à la matrice, puis à éluer le premier ligand de la matrice. Ces procédés et trousses peuvent par ailleurs être utilisés pour la recherche de médicaments.

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