Stereoselective production of hydroxyamide compounds from...

Details Stereoselective production of hydroxyamide compounds from... Stereoselective production of hydroxyamide compounds from...

C - Chemistry, Metallurgy

07

D

C07D 263/52 (2006.01) C07C 271/20 (2006.01) C07C 271/22 (2006.01) C07C 311/53 (2006.01) C07D 295/155 (2006.01) C07D 307/20 (2006.01) C07D 311/68 (2006.01) C07D 335/06 (2006.01) C07D 413/12 (2006.01) C07K 5/02 (2006.01)

Patent

CA 2072237

80/CSQ29 18474 TITLE OF THE INVENTION STEREOSELECTIVE PRODUCTION OF HYDROXYAMIDE COMPOUNDS FROM CHIRAL .alpha.-AMINO EPOXIDES ABSTRACT OF THE DISCLOSURE An efficient process for stereoselective preparation of a medicinally significant hydroxyamide compound of structural formula: Image comprises the addition of metalated amide enolates to chiral .alpha.-amino metalated epoxides. The hydroxyamide reaction products are useful as inhibitors of the HIV protease or of renin, or as intermediates in the preparation of inhibitors of the HIV protease or renin.

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