Method of inhibiting complement activation with human...

Details Method of inhibiting complement activation with human... Method of inhibiting complement activation with human...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2681741

A method of inhibiting complement activation mediated by C3b inhibitors in a subject includes administering a C3B inhibitor to the subject to inhibit at least one of C3b binding to factors B and properdin, inhibit C3 cleavage, inhibit the activation of neutrophils, monocytes, platelets, and endothelium; or inhibit the formation of C3a, C5a, and MAC.

La présente invention concerne un procédé d'inhibition de l'activation du complément par des inhibiteurs du C3b chez un sujet, comprenant l'administration d'un inhibiteur du C3b au sujet pour inhiber au moins l'une des liaisons du C3b aux facteurs B et à la properdine, inhiber la coupure du C3, inhiber l'activation des neutrophiles, des monocytes, des plaquettes, et de l'endothélium; ou inhiber la formation du C3a, du C5a, et du MAC.

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