Enhanced replication of hcv rna

Details Enhanced replication of hcv rna Enhanced replication of hcv rna

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) C12N 7/00 (2006.01) C12N 9/12 (2006.01) C12N 15/69 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2416633

This invention provides methods for generating cells that stably replicate sub- genomic virus replicons. This invention also provides methods of generating cells that have disabled PKR activity and that stably replicate HCV subgenomic replicons. The invention also provides methods of using the cells of the invention to screen for compounds that modulate viral RNA replication, including HCV RNA replication.

L'invention concerne des procédés permettant de générer des cellules qui répliquent de manière stable des réplicons de virus sous-génomiques. L'invention concerne également des procédés permettant de générer des cellules qui présentent une activité PKR déficiente et qui répliquent de manière stable des réplicons sous-génomiques du VHC. L'invention concerne en outre des procédés d'utilisation de ces cellules afin de rechercher par criblage des composés qui modulent la réplication d'ARN viraux, dont la réplication d'ARN du VHC.

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