Substituted 6-benzyl-4-oxopyrimidines, process for their...

Details Substituted 6-benzyl-4-oxopyrimidines, process for their... Substituted 6-benzyl-4-oxopyrimidines, process for their...

C - Chemistry, Metallurgy

07

D

C07D 239/52 (2006.01) A61K 31/505 (2006.01) C07D 239/36 (2006.01) C07D 239/46 (2006.01) C07D 239/56 (2006.01)

Patent

CA 2338014

The invention concerns novel substituted 6-benzyl-4-oxopyrimidines of general formula (A). These compounds inhibit reverse transcriptase encoded by human immunodeficiency virus (HIV) or pharmaceutically acceptable salts thereof, and find their application in the prevention and treatment of HIV infection and the treatment of the resulting acquired immune deficiency syndrome (AIDS). Pharmaceutical compositions containing the compounds and a method of use of the present compounds and other agents for the treatment of AIDS and viral infection by HIV are also envisaged.

L'invention concerne de nouveaux 6-benzyl-4-oxopyrimidines substituées présentant la formule générale (A). Ces composés inhibent la transcriptase inverse codée par le virus de l'immunodéficience humaine (VIH) ou des sels pharmaceutiquement acceptables de cette dernière. Ces composés présentent une grande utilité pour la prévention et le traitement de l'infection par le VIH et le traitement du syndrome de l'immunodéficience acquis (SIDA). L'invention a aussi pour objet des compositions pharmaceutiques contenant ces composés et un procédé d'utilisation de ces composés et d'autres agents pour le traitement du SIDA et de l'infection virale par le VIH.

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