Melatonin combination therapy for improving sleep quality

A - Human Necessities – 61 – K

Patent

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Details

A61K 45/06 (2006.01) A61K 31/4045 (2006.01) A61K 31/4985 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2551637

One aspect of the present invention relates to pharmaceutical compositions comprising a sedative agent; and melatonin or a melatonin analog, collectively referred to as "melatonin agents." In a preferred embodiment, the sedative agent is eszopiclone. The pharmaceutical compositions of the invention are useful in the treatment of various sleep disorders. In addition, the present invention also relates to a method of treating a patient suffering from a sleep abnormality or insomnia comprising administering a therapeutically effective amount of a pharmaceutical composition of the invention.

Un aspect de la présente invention concerne des compositions pharmaceutiques comprenant un agent sédatif ; ainsi que de la mélatonine ou un analogue de la mélatonine, collectivement appelés <= agents de mélatonine >=. Dans un mode de réalisation préféré, l'agent sédatif est l'eszopiclone. Les compositions pharmaceutiques selon l'invention sont utiles dans le traitement de divers troubles du sommeil. En outre, la présente invention concerne également une méthode de traitement d'un patient souffrant d'une anomalie du sommeil ou d'insomnie, consistant à administrer une quantité thérapeutiquement efficace d'une composition pharmaceutique de l'invention.

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