Method of screening ptp zeta activity promoter or inhibitor

Details Method of screening ptp zeta activity promoter or inhibitor Method of screening ptp zeta activity promoter or inhibitor

G - Physics

01

N

G01N 33/573 (2006.01) A61B 5/00 (2006.01) A61B 5/11 (2006.01) C12Q 1/44 (2006.01) G01N 33/15 (2006.01) G01N 33/68 (2006.01) A01K 67/027 (2006.01)

Patent

CA 2418267

An object of the present invention is to provide a remedy for dysfunction of central monoamine pathway, a method for screening a PTP.zeta. inhibitor or activator, which is useful as a remedy for gastric ulcer caused by Helicobacter pylori or pleiotrophin which is a heparin-binding secretory protein, and a non-human model animal being hyposensitive to a stimulant drug, VacA which is a toxin of Helicobacter pylori, or pleiotrophin by utilizing the physiological function of PTP.zeta.. After administering a subject material to PTP.zeta. knockout mice and wild-type mice, PTP.zeta. activity in the PTP.zeta. knockout mice and the wild-type mice is compared and evaluated to screen a PTP.zeta. inhibitor or activator. Examples of the comparison and the evaluation of the PTP.zeta. activity include the comparison and the evaluation of the function of central monoamine pathway such as changes in the level of central monoamine metabolism, sensitivity to a stimulant drug, the presence of dysfunction of mesolimbic dopamine pathway, level of acclimation to new circumstances, or stress-responsiveness, and the comparison and the evaluation of the level of binding to VacA, a toxin of Helicobacter pylori, or pleiotrophin.

L'invention porte sur un procédé de promotion de l'activité de promoteurs ou d'inhibiteurs du PTP xi , remède utile contre les troubles du système nerveux central dus à la monoamine et les ulcères gastriques causés par l<i>'Helicobacter pilori</i> ou la pléiotrophine, en utilisant les fonctions physiologiques du PTP xi ; et sur un animal modèle peu sensible aux excitants, aux toxines du <i>pilori</i> ou à la pléiotrophine. Le criblage de l'activité des promoteurs ou des inhibiteurs du PTP xi s'effectue par administration d'une substance d'essai de PTP xi à une souris à gène manquant et à une souris de type sauvage, puis par comparaison et évaluation de l'action du PTP xi sur ces animaux (par exemple la survenance de troubles du système nerveux central dus à la monoamine, les possibilités d'adaptation à un nouvel environnement, la réponse au stress, les possibilités de fixation de la toxine du <i>pilori</i> ou de la pléiotrophine).

Affiliated with

Also associated with

Rating

Method of screening ptp zeta activity promoter or inhibitor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of screening ptp zeta activity promoter or inhibitor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of screening ptp zeta activity promoter or inhibitor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1974238