C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 31/7052 (2006.01) A61K 31/7115 (2006.01) A61K 38/45 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 16/00 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/66 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2382470
A polypeptide having a nucleoside or nucleotide kinase activity, which comprises a wild-type nucleoside or nucleotide kinase mutated at at least one amino acid position within the active site of nucleoside or nucleotide kinase to increase kinase catalytic activity towards a given nucleotide or nucleoside analog compared to the wild-type nucleoside or nucleotide kinase. A polynucleotide coding for said polypeptide. Methods, including therapeutic ones, using said polypeptide and polynucleotide.
Deville-Bonne Dominique
Gallois-Montbrun Sarah
Giacomoni-Fernandes Veronique
Schneider Benoit
Veron Michel
Centre National de La Recherche Scientifique (c.n.r.s.)
Institut Pasteur
Robic
Universite Pierre Et Marie Curie
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