Hbv drug resistance drug resistance detection methods

Details Hbv drug resistance drug resistance detection methods Hbv drug resistance drug resistance detection methods

Category

C - Chemistry, Metallurgy

Subcategory

12

Subsubcategory

N

IPC codes

C12N 7/00 (2006.01) C07K 14/02 (2006.01) C12N 9/12 (2006.01) C12N 15/00 (2006.01) C12Q 1/70 (2006.01)

Type

Patent

Patent number

CA 2480382

Description

New polymorphisms in the nucleic acid sequences of the DNA polymerase/reverse transcriptase open reading frame and viral surface antigen open reading frame of the hepatitis B virus are reported. In particular, the present invention relates to the mutation YMDD .fwdarw. YSDD in the HBV reverse transcriptase domain and to the W196V mutation in the small HBV viral surface antigen. Said polymorphisms are affecting the detection of drug resistance mutations by genotypic methods and diagnostic kits based thereon. The present invention relates to methods and diagnostic kits for detection of a HBV virus comprising said nucleic acid polymorphisms. In particular, those methods utilizing oligonucleotides capable of hybridizing to said HBV nucleic acid polymorphisms are envisaged.

L'invention concerne des nouveaux polymorphismes dans des séquences d'acide nucléique du cadre de lecture ouvert de l'ADN polymérase/transcriptase inverse et du cadre de lecture ouvert de l'antigène de surface du virus de l'hépatite B (HBV). L'invention concerne en particulier la mutation YMDD ? YSDD dans le domaine de transcriptase inverse du HBV, et la mutation W196V dans le petit antigène de surface du virus HBV. Lesdits polymorphismes affectent la détection de mutations de résistance médicamenteuse effectuée au moyen de méthodes génotypiques et de kits diagnostiques basés sur lesdites méthodes. L'invention concerne également des méthodes et des kits diagnostiques de détection d'un virus HBV comprenant lesdits polymorphismes d'acide nucléique. L'invention concerne en particulier lesdites méthodes mettant en oeuvre des oligonucléotides pouvant s'hybrider avec lesdits polymorphismes d'acide nucléique.

Affiliated with

Also associated with

Rating

Hbv drug resistance drug resistance detection methods does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hbv drug resistance drug resistance detection methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hbv drug resistance drug resistance detection methods will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1975129