Use of fructose diphosphate to reduce cyclosporine dosages...

Details Use of fructose diphosphate to reduce cyclosporine dosages... Use of fructose diphosphate to reduce cyclosporine dosages...

Category

A - Human Necessities

Subcategory

61

Subsubcategory

K

IPC codes

A61K 38/13 (2006.01) A61K 31/70 (2006.01)

Type

Patent

Patent number

CA 2227337

Description

This invention discloses a method of using fructose-1,6-diphosphate (FDP) to help suppress the rejection of internal organs such as kidneys, hearts, etc. At least three major advantages of FDP in conjunction with organ transplants have been identified: (1) FDP can help reduce the unwanted proliferation of certain types of stimulated lymphocytes which would otherwise pose a risk of attacking the non-self cells in the transplanted organ; (2) FDP can also potentiate the effectiveness of cyclosporine as a transplant-protecting immunosuppressant, thereby allowing a reduction in CSA dosages, which in turn can reduce the likelihood and the severity of toxic side effects and other dangers of CSA treatment; (3) FDP can also reduce the amount of damage inflicted on an organ during the removal and storage steps required in organ transplantation.

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