Inhibition of the .beta.3 subunit of l-type ca2+ channels

Details Inhibition of the .beta.3 subunit of l-type ca2+ channels Inhibition of the .beta.3 subunit of l-type ca2+ channels

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01) C07K 14/705 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2479414

The present invention provides reagents and methods for identifying inhibitors of the L-type Ca2+ channel .beta.3 protein, which has been demonstrated to be involved in calcium signaling, insulin secretion, and glucose homeostasis. The invention also provides therapeutics and methods for treating a subject with one or more of diabetes, insulin resistance, impaired insulin secretion, and impaired glucose homeostasis, involving the use of inhibitors of an L-type Ca2+ channel .beta.3 subunit to provide a benefit to the subject.

L'invention concerne des réactifs et des procédés d'identification de la protéine .beta.¿3? du canal Ca?2+¿ de type L, dont l'implication a été démontrée dans la signalisation du calcium, la sécrétion d'insuline, et l'homéostase du glucose. L'invention concerne également des traitements et des méthodes de traitement d'un sujet présentant un ou plusieurs des états pathologiques suivants: diabète, résistance à l'insuline, sécrétion d'insuline déficiente, et homéostase du glucose déficiente; qui impliquent l'utilisation d'inhibiteurs d'une sous-unité .beta.¿3? du canal Ca?2+¿ de type L destinée à produire un effet bénéfique chez le sujet.

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