C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/12 (2006.01) A61K 31/70 (2006.01) A61K 31/706 (2006.01) A61K 31/7068 (2006.01) A61P 35/00 (2006.01) C07D 409/04 (2006.01) C07H 19/09 (2006.01)
Patent
CA 2338415
Patients suffering from cancer are treated by being administered a compound represented by formula: (1), wherein each R individually is H or an aliphatic or aromatic acyl group; A is selected from the group consisting of formulae (IIa, IIb, IIc, IId), wherein X is selected from the group consisting of hydrogen, fluorine, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano and nitro. The above compounds also inhibit DNA replication in mammalian cells.
.n traite des patients atteints de cancer en leur administrant un composé correspondant à la formule (1), formule dans laquelle chaque R représente individuellement H ou un groupe acyle aliphatique ou aromatique; A étant sélectionné dans le groupe constitué par les formules (IIa, IIb, IIc, et IId). Dans cette dernière formule, X est sélectionné dans le groupe constitué par de l'hydrogène, du fluor, un alcoxy, un alkyle, un haloalkyle, un alcényle, un haloalcényle, un alcynyle, un amino, un monoalkylamino, un dialkylamino, un cyano et un nitro. Ces composés inhibent également la réplication de l'ADN dans des cellules de mammifère.
Montgomery John A.
Secrist John A. III
Tiwari Kamal N.
Moffat & Co.
Southern Research Institute
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