C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/18 (2006.01) C07D 209/04 (2006.01) C07D 209/16 (2006.01) C07D 213/26 (2006.01) C07D 213/38 (2006.01) C07D 213/40 (2006.01) C07D 213/60 (2006.01) C07D 213/74 (2006.01) C07D 217/04 (2006.01) C07D 217/14 (2006.01) C07D 233/54 (2006.01) C07D 239/42 (2006.01) C07D 277/28 (2006.01) C07D 307/14 (2006.01) C07D 317/58 (2006.01)
Patent
CA 2623213
The invention relates to novel piperazine derivatives of formula I and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment or prevention of protozoal infections, especially malaria. wherein X represents -(CH2)o-2 - or -C(=O)-; n represents the integer 0, 1 or 2; R1-R4 as described in claim 1
L'invention concerne de nouveaux dérivés de pipérazine de la formule (1) et leur utilisation comme ingrédients actifs dans la préparation de compositions pharmaceutiques. L'invention porte également sur des aspects connexes, notamment des compositions pharmaceutiques contenant au moins l'un des composés précités et leur utilisation comme médicaments dans le traitement ou la prévention d'infections protozoales, en particulier la malaria. Formule (1) dans laquelle X représente -(CH2)o-2 - ou -C(=O)-; n représente l'entier 0, 1 ou 2; R1-R4 sont tels que décrits dans la revendication 1.
Binkert Christoph
Boss Christoph
Corminboeuf Olivier
Grisostomi Corinna
Meyer Solange
Actelion Pharmaceuticals Ltd
Gowling Lafleur Henderson Llp
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