Stabilized live vaccine

Details Stabilized live vaccine Stabilized live vaccine

A - Human Necessities

61

K

A61K 39/25 (2006.01) A61K 39/295 (2006.01) A61K 47/42 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2075521

Disclosed is a stabilized live vaccine containing a varicella virus and a stabilizer, wherein the vaccine is substantially free of Ca2+ ions and Mg2+ ions. This stabi- lized live vaccine is extremely excellent in storage sta- bility and heat resistance. Also disclosed is an improved stabilizer for a live varicella vaccine, comprising at least one member selected from gelatin and hydrolyzed gelatin, each being substantially free of Ca2+ ions and Mg2+ ions. The stabilizer can advantageously be used to stabilize a live vaccine containing a varicella virus. The substantial freedom of Ca2+ ions and Mg2+ ions can be attained by masking Ca2+ ions and Mg2+ ions present in a live vaccine containing a varicella virus and a stabilizer, with a chelating reagent, or by using as a stabilizer gelatin and/or a gelatin derivative after being purified to remove Ca2+ ions and/or Mg2+ ions contained therein.

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