Substituted n-phenyl...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 295/135 (2006.01) A61K 31/165 (2006.01) A61K 31/18 (2006.01) C07D 295/096 (2006.01) C07D 295/12 (2006.01) C07D 295/26 (2006.01)

Patent

CA 2458121

Compounds of formula (I) wherein R is methyl or mesyl; and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are described. Also described are processes for their preparation, pharmaceutical compositions containing it and their use in producing an elevation of PDH activity in a warm-blooded animal.

L'invention concerne des composés représentés par la formule générale (I) dans laquelle R représente un groupe méthyle ou mésyl, ainsi que des sels pharmaceutiquement acceptables et des esters hydrolysables <i>in vivo</i> de ces composés. L'invention concerne également des procédés destinés à la préparation de ces composés, des compositions pharmaceutiques renfermant ces composés et l'utilisation de ces composés pour augmenter l'activité de la PDH chez un animal à sang chaud.

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