Naphthamidine urokinase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 217/02 (2006.01) A61K 31/472 (2006.01) A61P 29/00 (2006.01) C07D 217/04 (2006.01) C07D 217/06 (2006.01) C07D 401/06 (2006.01) C07D 405/04 (2006.01)

Patent

CA 2407043

Compounds having formula (I) are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions, methods for the preparation of urokinase-inhibitors, and a method of inhibiting urokinase in a mammal.

Cette invention concerne des composés représentés par la formule (I) qui sont des inhibiteurs de l'urokinase et qui sont utiles pour le traitement de maladies dans lesquelles intervient l'urokinase. L'invention concerne également des compositions inhibant l'urokinase, des procédés de préparation de ces inhibiteurs et une méthode permettant d'inhiber l'urokinase chez un mammifère.

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