C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/231, 260/271
C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61K 31/675 (2006.01) C07F 9/547 (2006.01) C07F 9/6561 (2006.01)
Patent
CA 2031451
IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF NEUROTOXIC INJURY ABSTRACT A class of imidazo[1,2-a]pyridylnylalkyl compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a compound of this class alone or in a composition in an amount effective as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula: Image wherein each of R22, R23 and R24 is independently selected from hydrido, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cylohexyl and cycloheptyl; wherein each of Ym and Yn is a spacer group independently selected methylene and ethylene radicals which may be unsubstituted and from methylene radicals which may be substituted with a group selected from halo, hydroxy and oxo; wherein each of m and n is a number independently selected from zero to two, inclusive; wherein each X and T is one or more groups independently selected from hydrido, alkyl, cycloalkyl, halo, haloalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl and alkanoyl; or a pharmaceutically-acceptable salt thereof.
Adelstein Gilbert W.
Hansen Donald W. Jr.
Peterson Karen B.
Tsymbalov Sofya
G.d. Searle & Co.
Osler Hoskin & Harcourt Llp
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