C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/21 (2006.01) A61K 31/18 (2006.01) A61P 29/00 (2006.01) C07D 209/08 (2006.01) C07D 211/26 (2006.01) C07D 211/58 (2006.01) C07D 213/40 (2006.01) C07D 231/40 (2006.01) C07D 233/54 (2006.01) C07D 235/30 (2006.01) C07D 261/14 (2006.01) C07D 277/46 (2006.01) C07D 277/62 (2006.01) C07D 277/82 (2006.01) C07D 285/12 (2006.01)
Patent
CA 2667481
The present invention relates to new sulfonamide derivatives of formula (I), wherein R1-R8 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these same compounds, pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.
La présente invention concerne de nouveaux dérivés de sulfonamide de formule (I), dans laquelle R1 à R8 et Z sont tels que définis dans les revendications; et des antipodes ou racémates optiques et/ou leurs sels et/ou hydrates et/ou solvates, qui sont des antagonistes sélectifs de la bradyquinine B1. Ellle concerne des méthodes de production desdits composés, des compositions pharmacologiques contenant ces composés, et l'utilisation de ces composés pour le traitement ou la prévention d'états douloureux ou inflammatoires.
Beke Gyula
Bozo Eva
Farkas Sandor
Hornok Katalin
Keseru Gyorgy
Fetherstonhaugh & Co.
Richter Gedeon Nyrt
LandOfFree
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