Substituted triazinone derivatives

Details Substituted triazinone derivatives Substituted triazinone derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/53 (2006.01) A61P 3/10 (2006.01) A61P 25/28 (2006.01) A61P 33/06 (2006.01) A61P 35/00 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2729115

A triazinone derivative represented by formula (I) wherein: Z represents a bond, a carbonyl group, a methylene group optionally substituted by one or two groups chosen from a C1-6 alkyl group, a hydroxyl group, a Ci-.beta. alkoxy group; R1 rep- resents a 4-pyridine ring; R2 represents a hydrogen atom, a C1-6 alkyl; R3 represents a hydrogen atom, a C1-6 alkyl group; R2 and R3 may form together a 6 membered cycle with the nitrogens caring R2 and R3 optionally substituted; R4 represents: a phenyl ring, being optionally substituted; n represents 0 to 2; in form of a free base or of an addition salt with an acid. The compounds of the present invention have GSK3.beta. inhibitory activity and are useful as an active ingredient of a medicament for preventive and/or therapeutic treatment of diseases caused by abnormal activity of GSK3.beta. and more particularly of neurodegenerative diseases.

Linvention concerne un dérivé de triazinone de formule (I), qui se présente sous la forme d'une base libre ou d'un sel d'addition avec un acide. Dans ladite formule, Z représente une liaison, un groupe carbonyle, un groupe méthylène éventuellement substitué par un ou deux groupes choisis parmi un groupe alkyle C1-6, un groupe hydroxyle, un groupe alcoxy C1-6; R1 représente un noyau 4-pyridine; R2 représente un atome d'hydrogène, un alkyle C1-6; R3 représente un atome d'hydrogène, un groupe alkyle C1-6; R2 et R3 peuvent former ensemble un cycle à 6 chaînons, les azotes prenant en charge R2 et R3 éventuellement substitués; R4 représente un noyau phényle éventuellement substitué; n est compris entre 0 et 2. L'invention concerne en outre l'utilisation du dérivé de triazinone à des fins thérapeutiques.

Affiliated with

Also associated with

Rating

Substituted triazinone derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted triazinone derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted triazinone derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1977561