A method of identification of cells that show sensitivity to...

Details A method of identification of cells that show sensitivity to... A method of identification of cells that show sensitivity to...

G - Physics

01

N

G01N 33/574 (2006.01)

Patent

CA 2677986

The invention is based on the finding that cells that show (especially tyrosine) phosphorylation of FGF-R substrate 2 (FRS-2), in contrast to cells that lack such phosphorylation, allow a prediction that treatment with a modulator, especially an inhibitor, of Fibroblast Growth Factor-Receptor signaling will be successful in cells e.g. from biological samples from patients that show such phosphorylation. Therefore, the phosphorylation of FRS-2 can serve as a biomarker for the possibility of successful treatment. The invention relates to various methods, uses, kits and reagents useful in applying this biomarker.

L'invention se base sur la découverte que des cellules qui présentent (notamment la tyrosine) une phosphorylation du substrat FGF-R 2 (FRS-2), à l'inverse des cellules qui n'ont pas une telle phosphorylation, permet une prédiction que le traitement avec un modulateur, notamment un inhibiteur, de la signalisation du Récepteur de Facteur de Croissance des Fibroblastes sera réussi dans les cellules, par exemple, à partir d'échantillons biologiques de patients qui présentent une telle phosphorylation. Par conséquent, la phosphorylation de FRS-2 peut servir de biomarqueur pour la possibilité d'un traitement réussi. L'invention porte sur divers procédés, utilisations, coffrets et réactifs utiles dans l'application de ce biomarqueur.

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