C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C07K 14/72 (2006.01) C12N 15/09 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2446819
The present invention discloses the isolation and characterization of cDNA molecules encoding novel androgen receptor (AR) protein from Macaca mulatta. Also within the scope of the disclosure are recombinant vectors, recombinant host cells, methods of screening for modulators of Macaca mulatta AR (rhAR) activity, purified proteins and fusion proteins which comprise all or a portion of the rhAR protein, transgenic mice comprising a transgene encoding the rhAR protein, as well as production of antibodies against AR, or epitopes thereof.
L'invention concerne l'isolation et la caractérisation de molécules d'ADNc codant une nouvelle protéine du récepteur androgène (AR) du Macaca mulatta. L'invention concerne également des vecteurs recombinants, des cellules hôtes recombiantes, des méthodes de criblage de modulateurs de l'activité du Ar du Macaca mulatta (rhAR), des protéines purifiées et des protéines hybrides comprenant l'ensemble ou une partie de la protéine du rhAR, des souris transgéniques comprenant un transgène codant la protéine du rhAR, ainsi qu'une production d'anticorps contre le AR ou des épitopes de celui-ci.
Chen Fang
Towler Dwight A.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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