Nitrogen-containing heterocylic compounds, their production...

Details Nitrogen-containing heterocylic compounds, their production... Nitrogen-containing heterocylic compounds, their production...

C - Chemistry, Metallurgy

07

D

167/211, 260/251

C07D 403/10 (2006.01) A61K 31/395 (2006.01) C07D 213/80 (2006.01) C07D 239/36 (2006.01) C07D 239/91 (2006.01) C07D 401/10 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2037630

Abstract of the Disclosure Nitrogen-containing heterocyclic compounds of the formula (I): Image wherein Y is N or CH; R', which may be optionally bound through a hetero atom, is a hydrocarbon residue which may be substituted; R2 and R3 which may be same or different, are each independently hydrogen, cyano, nitro, optionally substituted lower alkyl, or -COD wherein D is alkoxy, hydroxy, halogen, or optionally substituted amino; or R2 and R3 are taken together to form a benzene ring which may be substituted; the dotted line is a chemical bond; Z is bound to a hetero nitrogen atom and is a group having the formula: Image wherein R4 is hydrogen, halogen or vitro, and R5 is a residue capable of forming an anion or a residue convertible into an anion; A is a direct bond or a spacer having atomic length of two or less between the phenylene group and the phenyl group; and n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof, have potent angiotensin II antagonist activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases, strokes, etc.

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