Process for the complete removal of protective groups on...

Details Process for the complete removal of protective groups on... Process for the complete removal of protective groups on...

C - Chemistry, Metallurgy

12

P

C12P 19/28 (2006.01) C12P 19/30 (2006.01)

Patent

CA 2211186

A process for the preparation of nucleoside diphosphate and triphosphate sugars wherein hydroxyl protective groups are removed enzymatically, and a process for the preparation of these sugars, which comprises coupling a nucleotide with a sugar-1-phosphate activated with a carbonyl bisazole and then removing the hydroxyl protective groups enzymatically.

L'invention concerne un procédé de préparation de composés du type nucléoside-diphosphate-sucre et nucléoside-triphosphate-sucre dont les groupes hydroxyle protecteurs ont été enlevés par voie enzymatique. Ce procédé consiste à coupler un nucléotide avec un sucre-1-phosphate activé par un carbonyle bisazole et ensuite à enlever les groupes hydroxyle protecteurs par voie enzymatique.

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