C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) C07K 14/005 (2006.01) C07K 19/00 (2006.01)
Patent
CA 2390104
The invention relates to a method for the transfer of molecular substances, for example proteins or nucleic acids in cells, in the case of using DNA combined with a possible gene expression. A prokaryotic nucleic acid-binding protein is used for the transfer, which is preferably obtained from a thermostable organism. Where the substance to be transferred is a nucleic acid, the protein forms a reversible complex with the nucleic acid. The prokaryotic protein condenses and compacts the nucleic acids. Said nucleic acids can be taken up in the target cells after suitable incubation.
La présente invention concerne un procédé de transfert de substances moléculaires telles que des protéines ou des acides nucléiques dans des cellules, ce procédé étant éventuellement lié à une expression génétique possible dans le cas de l'utilisation D'ADN. Pour ce transfert, on utilise une protéine procaryotique liant des acides nucléiques, de préférence issue d'un organisme thermostable. Dans le cas d'un transfert d'acides nucléiques, la protéine forme un complexe réversible avec l'acide nucléique, et la protéine procaryotique condense et comprime l'acide nucléique. Ces acides nucléiques peuvent être absorbés dans les cellules cibles après incubation correspondante.
Bohm Gerald
Esser Dirk
Acgt Pro Genomics Ag
Oyen Wiggs Green & Mutala Llp
LandOfFree
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