A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4355 (2006.01) A61K 8/63 (2006.01) A61P 35/00 (2006.01) A61Q 19/00 (2006.01)
Patent
CA 2452151
This invention concerns the use of cyclopamine in vivo on basal cell carcinomas to achieve therapeutic effect by causing differentiation of the tumor cells and, at the same time, highly efficient apoptotic death and removal of these tumor cells while preserving the normal tissue cells, including the undifferentiated cells of the normal epidermal basal layer and hair follicles. Causation of apoptosis by cyclopamine is by a non-genotoxic mechanism. These effects make the use of cyclopamine highly desirable in the treatment of basal cell carcinomas and other tumors that use the hedgehog/smoothened signal transduction pathway for proliferation and prevention of apoptosis.
L'invention concerne l'utilisation de cyclopamine in vivo sur des carcinomes baso-cellulaires afin d'obtenir un effet thérapeutique par réalisation d'un différentiation des cellules tumorales et, en même temps, d'une mort par apoptose très efficace et une élimination de ces cellules tumorales, tout en préservant les cellules tissulaires saines, y comprises les cellules non différentiées de la couche épidermique de la base et les follicules pileux. L'induction de l'apoptose par la cyclopamine se réalise par un mécanisme non génotoxique. Ces effets rendent très recherchée l'utilisation de la cyclopamine dans le traitement de carcinomes baso-cellulaires et d'autres tumeurs qui utilisent la voie du signal de transduction du signal hedgehog/smoothened aux fins de prolifération et de prévention de l'apoptose.
Avci Oktay
Tas Sinan
Borden Ladner Gervais Llp
Tas Sinan
LandOfFree
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