Interstitial deletion in chromosomal dna

Details Interstitial deletion in chromosomal dna Interstitial deletion in chromosomal dna

C - Chemistry, Metallurgy

12

N

C12N 15/01 (2006.01) C12N 9/64 (2006.01) C12N 15/10 (2006.01) C12N 15/85 (2006.01) C12N 15/90 (2006.01)

Patent

CA 2112673

2112673 9301292 PCTABS00019 Methods and compositions are provided for directing deletions, additions or substitutions in chromosomal DNA. Particularly, a sequence having homology to a target sequence is employed, joined to a sequence having homology to a repetitive sequence. Integration of the construct into a chromosome provides for a nested sequence of deletions related to the number and distance of the repetitive sequences from the target sequence.

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