Replication incompetent herpes viruses for use in gene therapy

Details Replication incompetent herpes viruses for use in gene therapy Replication incompetent herpes viruses for use in gene therapy

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) C12N 15/869 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2395576

Use of a replication incompetent herpes virus capable of delivering a gene to multiple connected sites within the nervous system, which virus comprises: (a) a mutation which prevents or reduces the expression of at least two immediate early genes; and (b) a heterologous gene operably linked to a promoter active during herpes virus latency; in the manufacture of a medicament for the treatment of a central nervous system disorder, a method of determining whether a gene has an effect on a phenotype associated with a central nervous system disorder and in a method of treatment of a disorder of the central nervous system.

La présente invention concerne l'utilisation d'une réplique d'herpèsvirus atténué capable de placer un gène en plusieurs sites connectés à l'intérieur du système nerveux. Ce virus présente: (a) une mutation qui prévient ou limite l'expression d'au moins deux gènes précoces; et (b) un gène hétérologue fonctionnellement lié à un promoteur actif pendant la latence de l'herpèsvirus. Ce virus s'utilise pour la fabrication d'un médicament destiné au traitement de troubles du système nerveux central. L'invention concerne également un procédé permettant de vérifier si un gène a un effet sur un phénotype associé à un trouble du système nerveux central. L'invention concerne enfin un procédé se rapportant au traitement d'un trouble du système nerveux central.

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