A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 38/00 (2006.01) C07K 16/24 (2006.01)
Patent
CA 2742802
The present disclosure relates to, inter alia, compositions containing an inhibitor of human complement and use of the compositions in methods for treating or preventing complement-associated disorders. In some embodiments, the inhibitor is chronically administered to patients. In some embodiments, the inhibitor is administered to a patient in an amount and with a fre-quency to maintain systemic complement inhibition and prevent breakthrough. In some embodiments, the compositions contain an antibody, or antigen-binding fragment thereof, that binds to a human complement component C5 protein or a fragment of the protein such as C5a or C5b.
La présente invention concerne, entre autres, des compositions contenant un inhibiteur de complément humain et l'utilisation des compositions dans des procédés de traitement ou de prévention de troubles associés au complément. Selon certains modes de réalisation, l'inhibiteur est administré aux patients de manière continue. Selon d'autres modes de réalisation l'inhibiteur est administré à un patient en une quantité et à une fréquence suffisantes pour maintenir l'inhibition systémique de complément et empêcher la réapparition des troubles. Selon certains modes de réalisation, les compositions contiennent un anticorps, ou un fragment de celui-ci de liaison à l'antigène, qui se lie à la protéine du composant C5 du complément humain ou à un fragment de ladite protéine tel que C5a ou C5b.
Bedrosian Camille
Bell Leonard
Rother Russell P.
Squinto Stephen P.
Alexion Pharmaceuticals Inc.
Borden Ladner Gervais Llp
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