C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/14 (2006.01) A61K 31/496 (2006.01) A61P 3/10 (2006.01) C07D 235/00 (2006.01) C07D 241/00 (2006.01) C07D 249/00 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01)
Patent
CA 2566108
The invention provides compounds of formula (I), prodrugs and stereoisomers thereof, and the pharmaceutically acceptable salts of the compounds, prodrugs, and stereoisomers, wherein R1, R2, R3, HET, n, Q, X, Y, and Z are as described herein; compositions thereof; and uses thereof in treating diabetic complications including diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, and the like.
L'invention concerne des composés de formule (I), des promédicaments et des stéréo-isomères de ces composés, ainsi que des sels pharmaceutiquement acceptables desdits composés, promédicaments et stéréo-isomères. Dans ladite formule (I), R?1¿, R?2¿, R?3¿, HET, n, Q, X, Y, et Z sont tels que définis dans la description. La présente invention concerne en outre des compositions correspondantes, ainsi que leurs utilisations pour traiter des complications diabétiques parmi lesquelles figurent la neuropathie diabétique, la néphropathie diabétique, la microangiopathie diabétique et analogue.
Hulin Bernard
Piotrowski David Walter
Pfizer Products Inc.
Torys Llp
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