Measurement of platelet activities

Details Measurement of platelet activities Measurement of platelet activities

C - Chemistry, Metallurgy

12

Q

C12Q 1/56 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2114719

Methods are provided for measuring the procoagulant activity of platelets in blood by means of a chromogenic assay which is specific for procoagulant phospholipids. These methods include the determination of the resting activity and/or excitability of platelets, which determines the threshold at which activating clotting factors (circulating in blood) are dangerous. Also methods are provided for screening drugs for their potential inhibitory effect on the activation of platelets.

éthodes pour mesurer l'activité procoagulante de plaquettes sanguines au moyen d'une bioanalyse chromogène qui est spécifique aux phospholipides procoagulants. Ces méthodes comprennent la détermination de l'activité de repos et/ou de l'excitabilité des plaquettes qui permet d'établir le seuil auquel les facteurs de coagulation activateurs (circulant dans le sang) deviennent dangereux. Sont décrites également des méthodes de dépistage des drogues en fonction de leur effet inhibiteur sur l'activation des plaquettes.

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