Heat-treated igm antibody preparations

Details Heat-treated igm antibody preparations Heat-treated igm antibody preparations

A - Human Necessities

61

K

167/139

A61K 39/395 (2006.01) C07K 16/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2039387

Mild heat-treatment of IgM antibody concentrates diminishes the potential to induce non-specific complement activation without significant loss of normal immunologic effector functions. These IgM immunoglobulin concentrates retain specific antigen binding properties and activate complement when bound to antigen. Preferred product includes at least 20% by weight IgM in an IgM/IgG antibody mixture. Heating is done at a temperature within the range of about 40°C to 62°C, preferably about 45° to 55°C, in a solution having an acid pH (preferably 4.0 to 5.0) for at least about 10 minutes.

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