Therapy for hyperglycemia, related disorders and erectile...

A - Human Necessities – 61 – K

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A61K 31/495 (2006.01) A61K 31/155 (2006.01) A61K 31/4985 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01) A61K 45/06 (2006.01) A61P 3/10 (2006.01) A61P 15/10 (2006.01)

Patent

CA 2679975

The invention relates to a methods, compositions and kits for treating hyperglycemia and related disorders, such as type 2 diabetes mellitus, impaired glucose tolerance, diabetic retinopathy, diabetic nephropathy and diabetic neuropathy, and to methods, compositions and kits for treating erectile dysfunction. The methods comprise administering an inhibitor of fatty acid oxidation to a subject in need thereof. In some embodiments, trimetazidine and metformin or a phosphodiesterase 5 inhibitor are administered.

La présente invention concerne des procédés, des compositions et des trousses pour traiter l'hyperglycémie et des troubles associés, tels que le diabète sucré de type 2, la tolérance déficiente au glucose, la rétinopathie diabétique, la néphropathie diabétique et la neuropathie diabétique, ainsi que des procédés, des compositions et des trousses pour traiter le dysfonctionnement érectile. Les procédés comprennent l'administration d'un inhibiteur d'oxydation des acides gras à un sujet qui en a besoin. Selon certains modes de réalisation, la trimétazidine et la metformine ou un inhibiteur de la phosphodiestérase de type 5 sont administrés.

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