A - Human Necessities – 61 – M
Patent
A - Human Necessities
61
M
A61M 1/14 (2006.01) A61L 33/00 (2006.01) A61M 1/36 (2006.01)
Patent
CA 2165443
Disclosed is a method for anticoagulation of blood in the extracorporeal circulation of blood, which comprises bringing an antithrombotic drug releasing member, which is formed by dispersing an antithrombotic drug in a polymer material, into contact with blood at the time of the extracorporeal circulation of blood, said antithrombotic drug being slightly soluble in water. In an antithrombotic drug releasing device to be used for the method of the present invention, an antithrombotic drug releasing member is contained in a vessel provided with a blood inlet and a blood outlet, or at least inner wall surface of the vessel is composed of the antithrombotic drug releasing member. Thereby, the antithrombotic drug can be continuously released from the antithrombotic drug releasing member. Therefore, blood coagulation in the blood circuit can be inhibited by bringing this antithrombotic drug releasing member into contact with blood at the time of the extracorporeal circulation.
Cette invention se rapporte à un procédé pour inhiber la coagulation du sang lors de l'établissement d'une circulation sanguine extracorporelle, en plaçant en contact avec le sang mis en circulation un élément de libération d'un médicament antithrombotique, préparé par dispersion d'un médicament antithrombotique difficilement soluble dans l'eau dans une substance macromoléculaire. Un dispositif de libération d'un médicament antithrombotique à utiliser dans ledit procédé comprend soit l'élément de libération du médicament contenu dans un récipient, comportant des orifices d'entrée et de sortie du sang à ses extrémités respectives, soit l'élément de libération du médicament constituant au moins la surface de la paroi interne dudit récipient. Dès lors que l'agent antithrombotique peut être libéré de façon prolongée par l'élément de libération du médicament, la coagulation du sang dans le circuit de circulation sanguine peut être inhibée par le contact du sang avec ledit élément de libération du sang lors de l'établissement d'une telle circulation extracorporelle.
Higashino Rika
Iguchi Seiichiro
Inai Masatoshi
Yamamoto Hiroaki
Yamato Minoru
Otsuka Pharmaceutical Co. Ltd.
Otsuka Pharmaceutical Factory Inc.
Riches Mckenzie & Herbert Llp
LandOfFree
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