Cyanoguanidine prodrugs

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 213/02 (2006.01) A61K 31/4425 (2006.01) A61P 35/00 (2006.01) C07D 213/75 (2006.01)

Patent

CA 2484671

Pyridyl cyanoguanidine compounds according to formula I wherein A, R1, R2, R5, R6, X1, X2, X3, X4, Y1, Y2, Y3, Y4 and n are as indicated in the description are useful as produgs in human and veterinary therapy of poliferative disease such as cancers.

L'invention concerne des composés de pyridylcyanoguanidine de formule (I), dans laquelle A, R¿1?, R¿2?, R¿5?, R¿6?, X¿1?, X¿2?, X¿3?, X¿4,? Y¿1?, Y¿2?, Y¿3?, Y¿4? et n ont la signification indiquée dans la description, lesdits composés servant de promédicaments dans la thérapie de maladies prolifératives telles que les cancers, chez l'homme et les animaux.

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