Process for producing 2-carbon-substituted carbapenem...

Details Process for producing 2-carbon-substituted carbapenem... Process for producing 2-carbon-substituted carbapenem...

C - Chemistry, Metallurgy

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C07D 477/00 (2006.01) A61K 31/40 (2006.01) C07D 477/02 (2006.01) C07D 477/14 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2030342

ABSTRACT A process for producing a 2-(unsubstituted or carbon- substituted)-1-carbapen-2-em-3-carboxylic acid derivative, which comprises reacting a 2- trifluoromethanesulfonyloxy-1-carbapen-2-em-3-carboxylic acid derivative or the 1-carbapen-2-em-3-carboxylie acid derivative derived from a 2-oxo-1-carbapenam-3-carboxylic aeid derivative and trifluoromethanesulfonic anhydride, and a stannane derivative in an inert solvent in the presence of a palladium compound and a salt.

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