C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2491632
The invention relates to compounds of formula (I) Wherein the substituents R1, R2 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, especially a neoplastic disease, in particular leukaemia, and a method for the treatment of such disease.
L'invention porte sur des composés de formule (I) dans laquelle les substituants R1, R2 et R4 sont tels qu'indiqués et explicités dans le descriptif, sur des procédés de préparation de ces composés, sur des compositions pharmaceutiques les contenant, sur leur utilisation éventuellement en combinaison avec un ou d'autres composés actifs d'un point de vue pharmaceutique dans le traitement d'une maladie réagissant à l'inhibition de l'activité de la protéine kinase, en particulier une maladie néoplasique telle que la leucémie, et sur un procédé de traitement de cette maladie.
Breitenstein Werner
Furet Pascal
Jacob Sandra
Manley Paul William
Fetherstonhaugh & Co.
Novartis Ag
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