Regulation of integrin surface expression

Details Regulation of integrin surface expression Regulation of integrin surface expression

A - Human Necessities

61

K

A61K 31/7105 (2006.01) A61K 31/713 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2734863

Disclosed are methods and compositions for preventing and treating conditions associated with platelet aggregation, comprising administering a therapeutically effective amount of a composition that modifies the interaction of DNAJC10 with .alpha.11b.beta.3 in a megakaryocyte, thereby altering the expression of .alpha.11b.beta.3 on the surface of the megakaryocyte.

L'invention concerne des procédés et des compositions, pour empêcher et pour traiter les états associés à une agrégation plaquettaire, qui comportent l'administration d'une quantité thérapeutique efficace d'une composition qui modifie l'interaction de DNAJC10 avec a11bß3 dans un mégacaryocyte, modifiant ainsi l'expression de a11bß3 sur la surface du mégacaryocyte.

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