Methods for differentiating and monitoring parathyroid and...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/26 (2006.01) G01N 33/543 (2006.01) G01N 33/577 (2006.01) G01N 33/58 (2006.01) G01N 33/74 (2006.01) G01N 33/78 (2006.01) C07K 1/22 (2006.01) C07K 14/635 (2006.01)

Patent

CA 2360020

The present invention relates to novel methods and devices for differentiating in a patient parathyroid diseases, such as hyperparathyroidism and related bone diseases, from normal or non-disease states. One detects whole or non- fragmented (1 to 84) parathyroid hormone in a biological sample and also a large non-whole parathyroid hormone peptide fragment that can function as a parathyroid hormone antagonist. By either comparing values or using independently the value of either the large non-whole parathyroid hormone peptide fragment, the whole parathyroid hormone, or the combination of these values one is able to differentiate parathyroid and bone related disease states, as well as differentiate such states from normal states.

L'invention concerne de nouveaux procédés et dispositifs pour distinguer chez un sujet des maladies de la parathyroïde, telles que l'hyperparathyroïdie et les maladies osseuses associées, des états normaux ou de l'absence de maladie. On détecte dans un prélèvement biologique l'hormone parathyroïde entière ou non fragmentée (1 à 84) ainsi qu'un grand fragment non entier du peptide de l'hormone parathyroïde qui peut fonctionner comme un antagoniste de l'hormone parathyroïde. En comparant les valeurs ou en utilisant indépendamment la valeur du grand fragment non entier du peptide de l'hormone parathyroïde, de l'hormone parathyroïde entière et de la combinaison de ces valeurs, on peut faire la distinction entre les états pathologiques liés à la parathyroïde ou aux os de même qu'entre ces états pathologiques et les états normaux.

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