Process for preparing intermediates for the manufacture of...

Details Process for preparing intermediates for the manufacture of... Process for preparing intermediates for the manufacture of...

C - Chemistry, Metallurgy

07

D

C07D 319/12 (2006.01) C07D 263/26 (2006.01) C07D 309/10 (2006.01) C07D 309/30 (2006.01) C07D 319/06 (2006.01)

Patent

CA 2435371

The invention relates to a process for the preparation of a substituted alkene of formula (I) wherein R1, R2 and R3 are independently of each other a protecting group for a hydroxy group or hydrogen and R4 is phenyl which is unsubstituted or mono- or disubstituted by alkoxy, which alkene constitutes an intermediate for the preparation of discodermolide and discodermolide analogues.

L'invention concerne un procédé de préparation d'un alcène substitué de formule (I): dans laquelle R¿1?, R¿2?, et R¿3? représentent, de manière indépendante les uns des autres, un groupe protecteur d'un groupe hydroxy ou d'un hydrogène, et R¿4? représente un groupe phényle non substitué, mono- ou disubstitué par un groupe alkoxy, cet alcène constituant un intermédiaire pour la préparation de discodermolide et d'analogues de discodermolide.

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