Sulfonamide derivatives and their use

Details Sulfonamide derivatives and their use Sulfonamide derivatives and their use

C - Chemistry, Metallurgy

07

D

C07D 211/22 (2006.01) A61K 31/18 (2006.01) A61K 31/195 (2006.01) A61K 31/33 (2006.01) C07C 201/14 (2006.01) C07C 205/59 (2006.01) C07C 311/16 (2006.01) C07C 311/39 (2006.01) C07C 311/46 (2006.01) C07C 323/67 (2006.01) C07D 211/46 (2006.01) C07D 211/60 (2006.01) C07D 211/62 (2006.01) C07D 285/12 (2006.01) C07D 285/125 (2006.01) C07D 307/68 (2006.01) C07D 333/38 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07K 5/02 (2006.01) C07B 61/00 (2006.01)

Patent

CA 2183428

Combinatorial libraries are disclosed which are represented by the formula (I): (T'-L)q-?-C(O)-L'-II' wherein: ? is a solid support; T'-L- is an identifier residue; and -L'-II' is a ligand/linker residue. These libraries contain aryl sulfonamides, N-acyl derivatives, and N-substituted pyrrolidines and piperidines of the formula: Y-A-CO-R1 which are inhibitors of serine proteases and carbonic anhydrase isozymes. They are useful in the treatment of hyper-coagulation disease and ocular diseases such as glaucoma.

L'invention se rapporte à des banques combinatoires de composés qui sont représentés par la formule (I) (T'-L)qp <S> -C(O)-L'-II' dans laquelle <S> est un support solide; T'-L- est un reste de séquence identificatrice; et -L'-II' est un reste de ligand/segment de liaison. Ces banques contiennent des sulfonamides d'aryle, des dérivés de N-acyle, des pyrrolidines et des piperidines N- substitués de la formule: Y-A-CO-R<1> qui sont des inhibiteurs de sérines protéases et d'isozymes anhydrase carbonique. Ces composés sont utilisés dans le traitement de l'hypercoagulation et de troubles occulaires tel que le glaucome.

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