Pharmaceutical compositions for buccal delivery of pain...

A - Human Necessities – 61 – K

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Details

A61K 9/107 (2006.01) A61K 9/00 (2006.01) A61K 31/4468 (2006.01) A61K 31/485 (2006.01) A61K 45/06 (2006.01) A61K 47/10 (2006.01) A61K 47/20 (2006.01)

Patent

CA 2494147

Pharmaceutical compositions comprising a narcotic analgesic in mixed micellar form are disclosed. The mixed micelles are formed from an alkali metal alkyl sulfate, and other micelle-forming compounds as described in the specification. Micelle size ranges between about 1 and 10 nanometers. Methods for making and using the compositions are also disclosed. A preferred method for administering the present composition is through the buccal mucosa of the mouth.

L'invention se rapporte à des compositions pharmaceutiques comportant un analgésique narcotique sous forme micellaire mixte. Les micelles mixtes sont formés à partir d'un sulfate d'alkyle de métal alcalin, et d'autres composés de formation des micelles sont décrits dans la spécification. Les micelles ont une taille comprise approximativement entre 1 et 10 nanomètres. L'invention se rapporte également à des procédés de fabrication et d'utilisation de ces compositions. Un procédé préféré d'administration de la présente composition consiste à traverser la muqueuse orale de la bouche.

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