Treatment of metastatic breast cancer with anthracyclines,...

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A61K 31/138 (2006.01) A61K 31/337 (2006.01) A61K 31/704 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2497180

An improved adjuvant treatment of metastatic breast cancer in which patients are administered an anthracycline chemotherapeutic agent and a taxane chemotherapeutic agent is provided in which a diphenyl compound which is a potent antagonist of histamine binding at the intracellular histamine receptor is initially administered prior to administration of the chemotherapeutic agents.

L'invention concerne un traitement adjuvant du cancer du sein métastatique, qui consiste à administrer au patient un agent chimiothérapeutique aux anthracyclines et un agent chimiothérapeutique aux taxanes, et à lier un composé diphényle, antagoniste puissant de l'histamine, avec le récepteur de l'histamine intracellulaire, qui est d'abord administré préalablement à l'administration des agents chimiothérapeutiques.

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