Novel screens to identify agents that modulate retinal blood...

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/02 (2006.01) A61K 31/192 (2006.01) A61K 31/196 (2006.01) A61K 38/17 (2006.01) A61K 38/22 (2006.01) A61K 49/00 (2006.01) A61P 27/06 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2485709

The present invention provides methods for determining or identifying compounds that modulate the function of an isolated retinal pericyte or blood vessel , wherein a change in the contractile state of said pericyte or blood vessel is determined in the presence of a test compound, said change indicating that the test compound modulates the function of pericytes and/or blood vessels.

La présente invention concerne des procédés pour déterminer ou identifier des composés qui modulent la fonction d'un péricyte ou d'un vaisseau sanguin rétinien isolé. Ces procédés consistent à déterminer une modification de l'état contractile du péricyte ou du vaisseau sanguin en présence d'un composé de test, ladite modification indiquant que le composé de test module la fonction de péricytes et/ou de vaisseaux sanguins.

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