Mitochondria activators

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/4745 (2006.01) A61K 31/047 (2006.01) A61K 31/122 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/22 (2006.01) A61K 47/42 (2006.01) A61P 3/10 (2006.01) A61P 25/14 (2006.01)

Patent

CA 2578347

It is intended to provide a mitochondria activator which contains as the active ingredient pyrroloquinoline quinone preferably together with coenzyme Q (in particular, reduced coenzyme Q); and a mitochondria activator which contains as the active ingredient citric acid preferably together with coenzyme Q (in particular, reduced coenzyme Q). Pyrroloquinoline quinone or citric acid and coenzyme Q (in particular, reduced coenzyme Q) exert a synergistic effect of activating mitochondria and this effect can be obtained at a high level even in a low dose. Thus, mitochondria activators having an improved safety and being useful in practice can be provided. It is also intended to provide drugs for preventing or treating diseases caused by mitochondrial dysfunction.

Cette invention a pour objectif de fournir un activateur de mitochondries contenant, comme ingrédient actif, de la pyrroloquinoline quinone de préférence accompagnée de coenzyme Q (en particulier, de coenzyme Q réduite); et un activateur de mitochondries contenant, comme ingrédient actif, de l'acide citrique de préférence accompagné de coenzyme Q (en particulier, de coenzyme Q réduite). La pyrroloquinoline quinone, ou l'acide citrique et la coenzyme Q (en particulier, la coenzyme Q réduite), exercent un effet synergique d'activation des mitochondries, et cet effet peut être obtenu à un niveau élevé, même à faible dose. Ainsi, des activateurs de mitochondries dont la sécurité est améliorée, et étant utiles en pratique, peuvent être fournis. Cette invention a également pour objectif de fournir des médicaments permettant de prévenir et de traiter les maladies causées par disfonctionnement des mitochondries.

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