C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/20 (2006.01) A61K 31/40 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/497 (2006.01) A61K 31/5377 (2006.01) C07D 207/22 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2500848
The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
La présente invention concerne des composés de dihydropyrrole qui sont utiles pour traiter des maladies prolifératives cellulaires, pour traiter des troubles associés à l'activité de la kinésine KSP et pour inhiber la kinésine KSP. L'invention concerne également des compositions qui comprennent lesdits composés, ainsi que leurs méthodes d'utilisation pour traiter le cancer chez des mammifères.
Breslin Michael J.
Coleman Paul J.
Cox Christopher D.
Hartman George D.
Mariano Brenda J.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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