C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/19 (2006.01) C07K 14/52 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2287538
The present invention provides novel truncated forms of vascular endothelial growth factor-related proteins (VRPs or VRPs) which are useful for the stimulation of angiogenesis in vitro and in vivo. The invention also provides nucleic acids encoding such novel truncated VRPs and methods of producing truncated VRPs. Pharmaceutical compositions comprising truncated VRPs and methods of gene therapy using the nucleic acids which code for truncated VRPs may be useful for the treatment of heart disease and for wound healing.
Cette invention se rapporte à de nouvelles formes tronquées de protéines apparentées au facteur de croissance endothéliale vasculaire (VRP) qui servent à stimuler l'engiogenèse in vitro et in vivo. Cette invention se rapporte également à des acides nucléiques codant ces nouvelles protéines VRP tronquées et à des procédés pour produire ces protéines VRP tronquées. Des compositions pharmaceutiques contenant ces protéines VRP tronquées et des procédés de thérapie génétique utilisant les acides nucléiques qui codent ces protéines VRP tronquées peuvent servir dans le traitement des maladies cardiaques et pour la cicatrisation des plaies.
Collateral Therapeutics
Smart & Biggar
LandOfFree
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